Nucleic Acid Purification

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Roche has been at the forefront of developing commercial NAP technology for two decades, offering solutions for labs of all sizes.

The history of nucleic acid purification can be written in two chapters: the quest for reliable, high-quality isolation and, thereafter, continual refinement of the process with the goal of greater efficiency.

Friedrich Meischer first isolated “nuclein” in 1869. In 1958, the centrifugation method of isolation that would later become the cornerstone of recombinant DNA technology in the ‘70s and ‘80s was first demonstrated. The production of high-quality DNA was possible, but it wasn’t yet efficient.

A shift in focus toward increasing the throughput of plasmid purification technology has occurred over the last two decades, primarily in the wake of genome-scale sequencing projects. Today, extraction kits are designed with robotics in mind, with multiplexed chemistries making extraction easier, safer and far more efficient. Laboratories can process tens of thousands of samples per day.

Roche Molecular Diagnostics has been at the forefront of automated sample preparation for nearly two decades. Today, MagNA Pure instruments and reagents and High Pure kits meet a wide range of throughput needs in labs around the world. With research and development continuing at a brisk pace, Roche remains focused on enhancing its customers’ workflows through automation, flexibility and consistency across all solutions.